SB 239063

Catalog No. A11562

SB 239063是一种强效选择性p38 MAPKα/β抑制剂(p38α的IC50=44 nM)。SB 239063对ERK, JNK1和其他激酶的选择性超过220倍；比SB 203580的选择性高约3倍。SB 239063减少炎症细胞因子的产生，并在体内口服后具有神经保护作用。

Technical details

Catalog Num	A11562
M. Wt	368.4
Formula	C20H21FN4O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	193551-21-2
Synonyms	SB239063, SB-239063
SMILES	COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F

Biological Activity

Targets

p38α	p38β
44 nM	44 nM

Solubility *

In vitro (25°C)	DMSO	59 mg/mL (160.15 mM)
	Water	Insoluble
	Ethanol	Warmed: 7 mg/mL (19 mM)
In vivo	5% DMSO+30% PEG 300+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.14 mL	135.72 mL	271.44 mL
0.5 mM	5.43 mL	27.14 mL	54.29 mL
1 mM	2.71 mL	13.57 mL	27.14 mL
5 mM	0.54 mL	2.71 mL	5.43 mL

*The above data is based on the productmolecular weight 368.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.