TPCA-1

Catalog No. A11579

TPCA-1是一种有效且选择性的人IκB激酶2（IKK-2）抑制剂，IKK-2的IC50 = 17.9 nM，而IKK-1的IC50为400nM。

Product Citations

Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.

Technical details

Catalog Num	A11579
M. Wt	279.29
Formula	C12H10FN3O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	507475-17-4
Synonyms	TPCA1
SMILES	C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F

Biological Activity

TPCA-1是一种有效且选择性的人IκB激酶2（IKK-2）抑制剂，IKK-2的IC50 = 17.9 nM，而IKK-1的IC50为400nM。

Targets

IKK2 (Cell-free assay)
17.9 nM

Solubility *

In vitro (25°C)	DMSO	49 mg/mL (175.44 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% Cremophor EL, 2% N,N-dimethylacetamide	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.81 mL	179.03 mL	358.05 mL
0.5 mM	7.16 mL	35.81 mL	71.61 mL
1 mM	3.58 mL	17.9 mL	35.81 mL
5 mM	0.72 mL	3.58 mL	7.16 mL

*The above data is based on the productmolecular weight 279.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.