Torin 2

Catalog No. A11586

Torin 2 是有效的选择性mTOR抑制剂 (IC50 = 2.1 nM)。在PI3K上显示mTOR的800倍细胞选择性（mTOR和PI3K的细胞EC50值分别为0.25和200 nM）。

Product Citations

Diane Yang, .et al. Pancreatic Differentiation of Stem Cells Reveals Pathogenesis of a Syndrome of Ketosis-Prone Diabetes, Diabetes, 2021, Oct;70(10):2419-2429 PMID: 34344789

Technical details

Catalog Num	A11586
M. Wt	432.4
Formula	C24H15F3N4O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1223001-51-1
Synonyms	Torin2
SMILES	C1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=CC(=CC4=C32)C5=CN=C(C=C5)N)C(F)(F)F

Biological Activity

Torin 2 是有效的选择性mTOR抑制剂 (IC50 = 2.1 nM)。在PI3K上显示mTOR的800倍细胞选择性（mTOR和PI3K的细胞EC50值分别为0.25和200 nM）。

Targets

mTOR (p53?/? MEFs)	ATM (PC3 cells)	ATR (PC3 cells)	DNA-PK (PC3 cells)
0.25 nM	28 nM(EC50)	35 nM(EC50)	118 nM(EC50)

Solubility *

In vitro (25°C)	DMSO	18 mg/mL (41.63 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	1.4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.13 mL	115.63 mL	231.27 mL
0.5 mM	4.63 mL	23.13 mL	46.25 mL
1 mM	2.31 mL	11.56 mL	23.13 mL
5 mM	0.46 mL	2.31 mL	4.63 mL

*The above data is based on the productmolecular weight 432.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.