Licofelone
Catalog No. A11697
Licofelone是一种COX/LOX双重抑制剂，被认为是治疗骨关节炎的药物。它可能会降低与其他仅抑制COX（环氧合酶）的非甾体类抗炎药有关的胃肠道毒性。利福非酮是第一种同时抑制两者的药物。
- Silke Neumann, .et al. Improved Antitumor Activity of a Therapeutic Melanoma Vaccine through the Use of the Dual COX-2/5-LO Inhibitor Licofelone, Front Immunol, 2016, 7: 537 PMID: 27994586
| Catalog Num | A11697 |
|---|---|
| M. Wt | 379.88 |
| Formula | C23H22ClNO2 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 156897-06-2 |
| Synonyms | |
| SMILES | CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C |
Licofelone是一种COX/LOX双重抑制剂，被认为是治疗骨关节炎的药物。它可能会降低与其他仅抑制COX（环氧合酶）的非甾体类抗炎药有关的胃肠道毒性。利福非酮是第一种同时抑制两者的药物。
| In vitro | DMSO | 16 mg/mL (42.11 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (7.89 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.32 mL | 131.62 mL | 263.24 mL |
| 0.5 mM | 5.26 mL | 26.32 mL | 52.65 mL |
| 1 mM | 2.63 mL | 13.16 mL | 26.32 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
*The above data is based on the productmolecular weight 379.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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