VU 0357121

Catalog No. A11754

VU 0357121是代谢型谷氨酸受体5（mGlu5）的正变构调节剂（PAM），EC50 = 33 nM，Glumax为92％。

Technical details

Catalog Num	A11754
M. Wt	305.3
Formula	C17H17F2NO2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	433967-28-3
Synonyms	VU0357121,VU-0357121
SMILES	CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F

Biological Activity

VU 0357121是代谢型谷氨酸受体5（mGlu5）的正变构调节剂（PAM），EC50 = 33 nM，Glumax为92％。

Targets

mGluR5
30 nM(EC50)

Solubility *

In vitro	DMSO	56 mg/mL (183.41 mM)
	Water	Insoluble
	Ethanol	19 mg/mL (62.23 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.75 mL	163.77 mL	327.55 mL
0.5 mM	6.55 mL	32.75 mL	65.51 mL
1 mM	3.28 mL	16.38 mL	32.75 mL
5 mM	0.66 mL	3.28 mL	6.55 mL

*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.