RepSox (SJN 2511)

Catalog No. A11762

RepSox (SJN 2511)是TGF-βI型受体ALK5的选择性抑制剂（ALK5自磷酸化和ALK5结合的IC50值分别为0.004和0.023μM）。

Product Citations

Wojciech J Szlachcic, .et al. SARS-CoV-2 infects an in vitro model of the human developing pancreas through endocytosis, iScience, 2022, Jul 15;25(7) PMID: 35756892
Xu H, .et al. Androgen receptor reverses the oncometabolite R-2-hydroxyglutarate-induced prostate cancer cell invasion via suppressing the circRNA-51217/miRNA-646/TGFβ1/p-Smad2/3 signaling, Cancer Lett, 2020, Mar 1;472:151-164 PMID: 31846689

Technical details

Catalog Num	A11762
M. Wt	287.32
Formula	C17H13N5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	446859-33-2
Synonyms	E-616452, SJN 2511, ALK 5 inhibitor
SMILES	CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4

Biological Activity

RepSox (SJN 2511)是TGF-βI型受体ALK5的选择性抑制剂（ALK5自磷酸化和ALK5结合的IC50值分别为0.004和0.023μM）。

Targets

TGFβR1(ALK5) (Cell-free assay)
4 nM

Solubility *

In vitro	DMSO	49 mg/mL (170.54 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.8 mL	174.02 mL	348.04 mL
0.5 mM	6.96 mL	34.8 mL	69.61 mL
1 mM	3.48 mL	17.4 mL	34.8 mL
5 mM	0.7 mL	3.48 mL	6.96 mL

*The above data is based on the productmolecular weight 287.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.