BAY 80-6946 (Copanlisib)

Catalog No. A11766

BAY 80-6946 (Copanlisib)是具有潜在抗肿瘤活性的磷酸肌醇3激酶（PI3K）抑制剂。

Product Citations

Shin SM, .et al. Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth, Sci Adv, 2020, Jan 15;6(3):eaay2174 PMID: 31998840

Technical details

Catalog Num	A11766
M. Wt	480.2
Formula	C23H28N8O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1032568-63-0
Synonyms	BAY80-6946, BAY806946
SMILES	COC1=C(C=CC2=C1N=C(N3C2=NCC3)NC(=O)C4=CN=C(N=C4)N)OCCCN5CCOCC5

Biological Activity

BAY 80-6946 (Copanlisib)是具有潜在抗肿瘤活性的磷酸肌醇3激酶（PI3K）抑制剂。

Solubility *

In vitro	DMSO	Insoluble
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.82 mL	104.12 mL	208.25 mL
0.5 mM	4.16 mL	20.82 mL	41.65 mL
1 mM	2.08 mL	10.41 mL	20.82 mL
5 mM	0.42 mL	2.08 mL	4.16 mL

*The above data is based on the productmolecular weight 480.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.