Prucalopride

Catalog No. A11771

Prucalopride是一种选择性的，高亲和力的5-HT4受体激动剂，作用于5-HT4A和5-HT4B受体，Ki分别为2.5 nM和8 nM，比作用于5-HT受体亚型选择性高290倍以上。

Product Citations

Pierre Meschin, .et al. p11 modulates calcium handling through 5-HT4R pathway in rat ventricular cardiomyocytes., Cell Calcium, 2015, Dec;58(6):549-57 PMID: 26427584

Technical details

Catalog Num	A11771
M. Wt	367.9
Formula	C18H26ClN3O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	179474-81-8
Synonyms	Resolor
SMILES	COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl

Biological Activity

Prucalopride是一种选择性的，高亲和力的5-HT4受体激动剂，作用于5-HT4A和5-HT4B受体，Ki分别为2.5 nM和8 nM，比作用于5-HT受体亚型选择性高290倍以上。

Targets

Target	Value
5-HT4A	ki: 2.5nM
5-HT4B	ki: 8nM
5-HT3	ki: 3.822μM
5-HT1A	ki: >10μM
5-HT1B	ki: >10μM
5-HT1D	ki: >10μM
5-HT1E	ki: >10μM
5-HT1F	ki: >10μM
5-HT2A	ki: >10μM
5-HT2B	ki: >10μM
5-HT2C	ki: >10μM
5-HT5A	ki: >10μM
5-HT6	ki: >10μM
5-HT7	ki: >10μM

Solubility *

In vitro	DMSO	52 mg/mL (141.35 mM)
	Water	Insoluble
	Ethanol	33 mg/mL (89.7 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.18 mL	135.91 mL	271.81 mL
0.5 mM	5.44 mL	27.18 mL	54.36 mL
1 mM	2.72 mL	13.59 mL	27.18 mL
5 mM	0.54 mL	2.72 mL	5.44 mL

*The above data is based on the productmolecular weight 367.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.