LY2811376

Catalog No. A11776

LY2811376是第一种可口服的非肽类BACE1抑制剂，可在动物体内产生显着的Aβ降低作用。

Technical details

Catalog Num	A11776
M. Wt	320.4
Formula	C15H14F2N4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1194044-20-6
Synonyms	LY 2811376, LY-2811376
SMILES	C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F

Biological Activity

LY2811376是第一种可口服的非肽类BACE1抑制剂，可在动物体内产生显着的Aβ降低作用。

Targets

BACE1	Aβ
239 nM-249 nM	~300 nM(EC50)

Solubility *

In vitro (25°C)	DMSO	16 mg/mL (49.94 mM)
	Water	Insoluble
	Ethanol	63 mg/mL (196.65 mM)
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.21 mL	156.05 mL	312.11 mL
0.5 mM	6.24 mL	31.21 mL	62.42 mL
1 mM	3.12 mL	15.61 mL	31.21 mL
5 mM	0.62 mL	3.12 mL	6.24 mL

*The above data is based on the productmolecular weight 320.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.