PF 670462
Catalog No. A11781
PF-670462是有效的、选择性CK1ε和CK1δ抑制剂，IC50分别为7.7和14 nM，其选择性是其他42种常见激酶的30倍以上。
| Catalog Num | A11781 |
|---|---|
| M. Wt | 410.3 |
| Formula | C19H20FN5.2HCl |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 950912-80-8 |
| Synonyms | PF670462 |
| SMILES | C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl |
PF-670462是有效的、选择性CK1ε和CK1δ抑制剂，IC50分别为7.7和14 nM，其选择性是其他42种常见激酶的30倍以上。
| In vitro | DMSO | 80 mg/mL (194.97 mM) | |
| Water | 80 mg/mL (194.97 mM) | ||
| Ethanol | 27 mg/mL (65.79 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.37 mL | 121.86 mL | 243.72 mL |
| 0.5 mM | 4.87 mL | 24.37 mL | 48.74 mL |
| 1 mM | 2.44 mL | 12.19 mL | 24.37 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.87 mL |
*The above data is based on the productmolecular weight 410.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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