GSK 1210151A (I-BET151)

Catalog No. A11783

GSK 1210151A (I-BET151)是溴结构域和额外末端(BET)家族蛋白BRD2,BRD3和BRD4的新型选择性抑制剂。
  • Momeny M, .et al. Inhibition of bromodomain and extraterminal domain reduces growth and invasive characteristics of chemoresistant ovarian carcinoma cells, Anticancer Drugs, 2018, Nov;29(10):1011-1020 PMID: 30096128
Catalog Num A11783
M. Wt 415.4
Formula C23H21N5O3
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1300031-49-5
Synonyms GSK1210151A
SMILES CC1=C(C(=NO1)C)C2=C(C=C3C(=C2)N=CC4=C3N(C(=O)N4)[C@H](C)C5=CC=CC=N5)OC
GSK 1210151A (I-BET151)是溴结构域和额外末端(BET)家族蛋白BRD2,BRD3和BRD4的新型选择性抑制剂。
Targets
BRD3 (Cell-free assay) BRD2 (Cell-free assay) BRD4 (Cell-free assay)
0.25 μM0.5 μM0.79 μM
In vitro DMSO Insoluble
Water Insoluble
Ethanol 27 mg/mL (64.99 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.07 mL 120.37 mL 240.73 mL
0.5 mM 4.81 mL 24.07 mL 48.15 mL
1 mM 2.41 mL 12.04 mL 24.07 mL
5 mM 0.48 mL 2.41 mL 4.81 mL

*The above data is based on the productmolecular weight 415.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.