Ulixertinib (BVD-523, VRT752271)

Catalog No. A11794

Ulixertinib (BVD-523,VRT752271)是ERK蛋白激酶的吡咯抑制剂。
  • Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
Catalog Num A11794
M. Wt 433.3
Formula C21H22Cl2N4O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 869886-67-9
Synonyms
SMILES CC(C)NC1=NC=C(C(=C1)C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)Cl
Ulixertinib (BVD-523,VRT752271)是ERK蛋白激酶的吡咯抑制剂。
Targets
ERK1 ERK2
N/A<0.3 nM
In vitro DMSO 80 mg/mL (184.61 mM)
Water Insoluble
Ethanol 14 mg/mL (32.3 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.08 mL 115.39 mL 230.79 mL
0.5 mM 4.62 mL 23.08 mL 46.16 mL
1 mM 2.31 mL 11.54 mL 23.08 mL
5 mM 0.46 mL 2.31 mL 4.62 mL

*The above data is based on the productmolecular weight 433.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.