Rofecoxib (Vioxx)

Catalog No. A11918

Rofecoxib (Vioxx)是一种COX-2抑制剂，IC50值为18 nM。

Technical details

Catalog Num	A11918
M. Wt	314.35
Formula	C17H14O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	162011-90-7
Synonyms	Vioxx
SMILES	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3

Biological Activity

Rofecoxib (Vioxx)是一种COX-2抑制剂，IC50值为18 nM。

Targets

COX-2
18 nM

Solubility *

In vitro (25°C)	DMSO	62 mg/mL (197.22 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.81 mL	159.06 mL	318.12 mL
0.5 mM	6.36 mL	31.81 mL	63.62 mL
1 mM	3.18 mL	15.91 mL	31.81 mL
5 mM	0.64 mL	3.18 mL	6.36 mL

*The above data is based on the productmolecular weight 314.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.