IOX 2

Catalog No. A11924

IOX2是一种有效的HIF-1α脯氨酰羟化酶2（PHD2）抑制剂，在无细胞分析中的IC50为21 nM，选择性是JMJD2A，JMJD2C，JMJD2E，JMJD3或2OG加氧酶FIH的100倍以上。

Product Citations

Mun Chiang Chan, etc. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS One. 2015; 10(7): e0132004.

Technical details

Catalog Num	A11924
M. Wt	352.3
Formula	C19H16N2O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	931398-72-0
Synonyms	IOX-2, IOX2
SMILES	C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O

Biological Activity

IOX2是一种有效的HIF-1α脯氨酰羟化酶2（PHD2）抑制剂，在无细胞分析中的IC50为21 nM，选择性是JMJD2A，JMJD2C，JMJD2E，JMJD3或2OG加氧酶FIH的100倍以上。

Targets

PHD2 (Cell-free assay)
21 nM

Solubility *

In vitro (25°C)	DMSO	7 mg/mL (19.86 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	28.38 mL	141.92 mL	283.85 mL
0.5 mM	5.68 mL	28.38 mL	56.77 mL
1 mM	2.84 mL	14.19 mL	28.38 mL
5 mM	0.57 mL	2.84 mL	5.68 mL

*The above data is based on the productmolecular weight 352.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.