ACY-1215 (Rocilinostat)

Catalog No. A11940

ACY-1215 (Rocilinostat)是一种选择性HDAC6抑制剂，从而通过Hsp90的超乙酰化作用破坏Hsp90蛋白伴侣系统，并防止随后的总蛋白降解。

Technical details

Catalog Num	A11940
M. Wt	433.5
Formula	C24H27N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1316214-52-4
Synonyms	ACY1215
SMILES	C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO

Biological Activity

ACY-1215 (Rocilinostat)是一种选择性HDAC6抑制剂，从而通过Hsp90的超乙酰化作用破坏Hsp90蛋白伴侣系统，并防止随后的总蛋白降解。

Targets

Target	Value
HDAC6	IC50: 4.7nM
HDAC2	IC50: 48nM
HDAC3	IC50: 51nM
HDAC1	IC50: 58nM
HDAC8	IC50: 100nM
HDAC7	IC50: 1.4μM
HDAC5	IC50: 5μM
HDAC4	IC50: 7μM
HDAC9	IC50: >10μM
HDAC11	IC50: >10μM
Sirtuin1	IC50: >10μM
Sirtuin2	IC50: >10μM

Solubility *

In vitro (25°C)	DMSO	73 mg/mL (168.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.07 mL	115.34 mL	230.68 mL
0.5 mM	4.61 mL	23.07 mL	46.14 mL
1 mM	2.31 mL	11.53 mL	23.07 mL
5 mM	0.46 mL	2.31 mL	4.61 mL

*The above data is based on the productmolecular weight 433.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.