Apoptosis Activator 2

Catalog No. A11944

Apoptosis Activator 2 强烈诱导caspase-3激活，PARP裂解和DNA片段化，导致细胞破坏（依赖Apaf-1），IC50为约4μM，对HMEC，PREC或MCF-10A细胞无效。

Technical details

Catalog Num	A11944
M. Wt	306.1
Formula	C15H9Cl2NO2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	79183-19-0
Synonyms
SMILES	C1=CC=C2C(=C1)C(=O)C(=O)N2CC3=CC(=C(C=C3)Cl)Cl

Biological Activity

Apoptosis Activator 2 强烈诱导caspase-3激活，PARP裂解和DNA片段化，导致细胞破坏（依赖Apaf-1），IC50为约4μM，对HMEC，PREC或MCF-10A细胞无效。

Targets

Caspase-3

Solubility *

In vitro	DMSO	53 mg/mL (173.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.67 mL	163.35 mL	326.69 mL
0.5 mM	6.53 mL	32.67 mL	65.34 mL
1 mM	3.27 mL	16.33 mL	32.67 mL
5 mM	0.65 mL	3.27 mL	6.53 mL

*The above data is based on the productmolecular weight 306.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.