Zotarolimus

Catalog No. A11950

Zotarolimus是一种免疫抑制剂，可以抑制FKBP-12结合的IC50为2.8nM。。它是雷帕霉素的半合成衍生物。它设计用于以磷酸胆碱为载体的支架。

Technical details

Catalog Num	A11950
M. Wt	966.21
Formula	C52H79N5O12
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	221877-54-9
Synonyms	A 179578, ABT 578, Resolute, 42-(1-Tetrazolyl)rapamycin
SMILES	C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@@H]([C@@H](C4)OC)N5C=NN=N5)C)/C)O)OC)C)C)/C)OC

Biological Activity

Zotarolimus是一种免疫抑制剂，可以抑制FKBP-12结合的IC50为2.8nM。。它是雷帕霉素的半合成衍生物。它设计用于以磷酸胆碱为载体的支架。

Targets

FKBP-12
2.8 nM

Solubility *

In vitro	DMSO	89 mg/mL (92.11 mM)
	Water	Insoluble
	Ethanol	89 mg/mL (92.11 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.35 mL	51.75 mL	103.5 mL
0.5 mM	2.07 mL	10.35 mL	20.7 mL
1 mM	1.03 mL	5.17 mL	10.35 mL
5 mM	0.21 mL	1.03 mL	2.07 mL

*The above data is based on the productmolecular weight 966.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.