P505-15 (PRT062607, BIIB057)

Catalog No. A11952

P505-15 (PRT062607,BIIB057)是一种新型的，高度选择性的，Syk抑制剂（SYK IC（50）= 1 nM），具有比SYK活性至少高80倍的抗SYK活性。

Product Citations

Li T, .et al. Bruton's tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma, Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190

Technical details

Catalog Num	A11952
M. Wt	393.45
Formula	C19H23N9O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1370261-96-3
Synonyms	P50515, PRT062607
SMILES	CC(=O)O.C1CC[C@H]([C@H](C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N

Biological Activity

P505-15 (PRT062607,BIIB057)是一种新型的，高度选择性的，Syk抑制剂（SYK IC（50）= 1 nM），具有比SYK活性至少高80倍的抗SYK活性。

Solubility *

In vitro (25°C)	DMSO	85 mg/mL (197.71 mM)
	Water	85 mg/mL (197.71 mM)
	Ethanol	Insoluble
In vivo	Saline	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.42 mL	127.08 mL	254.16 mL
0.5 mM	5.08 mL	25.42 mL	50.83 mL
1 mM	2.54 mL	12.71 mL	25.42 mL
5 mM	0.51 mL	2.54 mL	5.08 mL

*The above data is based on the productmolecular weight 393.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.