Bay 11-7821

Catalog No. A11957

Bay 11-7821是TNF-α刺激的IκBα磷酸化的不可逆抑制剂。

Product Citations

Ali Nasrollahzadeh, .et al. Blockade of Nuclear Factor-??b (NF-??b) Pathway Using Bay 11-7082 Enhances Arsenic Trioxide-Induced Antiproliferative Activity in U87 Glioblastoma Cells, Rep Biochem Mol Biol, 2022, Jan;10(4):602-613 PMID: 35291620
Ali Nasrollahzadeh, .et al. Arsenic trioxide and BIBR1532 synergistically inhibit breast cancer cell proliferation through attenuation of NF-κB signaling pathway, Life Sci, 2020, Jul 6;257:118060 PMID: 32645343
Momeny M, .et al. Blockade of nuclear factor-κB (NF-κB) pathway inhibits growth and induces apoptosis in chemoresistant ovarian carcinoma cells, Int J Biochem Cell Biol, 2018, Jun;99:1-9 PMID: 29567488

Technical details

Catalog Num	A11957
M. Wt	207.25
Formula	C10H9NO2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	19542-67-7
Synonyms	Bay-11-7821, Bay 117821, Bay117821,Bay 11-7082, Bay-11-7082, Bay11-7082
SMILES	CC1=CC=C(C=C1)S(=O)(=O)/C=C/C#N

Biological Activity

Bay 11-7821是TNF-α刺激的IκBα磷酸化的不可逆抑制剂。

Targets

E2-conjugating enzymes (Cell-free assay)	IκBα?phosphorylation (Tumor cells)
N/A	10 μM

Solubility *

In vitro (25°C)	DMSO	39 mg/mL (188.17 mM)
	Water	Insoluble
	Ethanol	10 mg/mL (48.25 mM)
In vivo	5% DMSO+corn oil	7 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	48.25 mL	241.25 mL	482.51 mL
0.5 mM	9.65 mL	48.25 mL	96.5 mL
1 mM	4.83 mL	24.13 mL	48.25 mL
5 mM	0.97 mL	4.83 mL	9.65 mL

*The above data is based on the productmolecular weight 207.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.