CI994 (Tacedinaline)

Catalog No. A11964

CI994 (Tacedinaline)是一种组蛋白脱乙酰基酶（HDAC）抑制剂，可在活细胞中诱导组蛋白超乙酰化。

Technical details

Catalog Num	A11964
M. Wt	269.3
Formula	C15H15N3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	112522-64-2
Synonyms	CI-994, CI 994, Acetyldinaline, Goe 5549, G? 5549. PD 123654
SMILES	CC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N

Biological Activity

CI994 (Tacedinaline)是一种组蛋白脱乙酰基酶（HDAC）抑制剂，可在活细胞中诱导组蛋白超乙酰化。

Targets

HDAC1 (Cell-free assay)	HDAC2	HDAC3
0.9 μM	0.9 μM	1.2 μM

Solubility *

In vitro (25°C)	DMSO	51 mg/mL (189.37 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.13 mL	185.67 mL	371.33 mL
0.5 mM	7.43 mL	37.13 mL	74.27 mL
1 mM	3.71 mL	18.57 mL	37.13 mL
5 mM	0.74 mL	3.71 mL	7.43 mL

*The above data is based on the productmolecular weight 269.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.