BML-275 (Dorsomorphin)

Catalog No. A11970

BML-275 (Dorsomorphin)是一种可渗透细胞的吡唑并嘧啶化合物，显示为AMP激活的蛋白激酶（AMPK）和脂肪酸合酶抑制剂。

Product Citations

Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078

Technical details

Catalog Num	A11970
M. Wt	399.5
Formula	C24H25N5O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	866405-64-3
Synonyms	BML275, BML 275
SMILES	C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3

Biological Activity

BML-275 (Dorsomorphin)是一种可渗透细胞的吡唑并嘧啶化合物，显示为AMP激活的蛋白激酶（AMPK）和脂肪酸合酶抑制剂。

Targets

AMPK
109 nM(Ki)

Solubility *

In vitro	DMSO	Warmed: 1 mg/mL (2.5 mM)
	Water	Insoluble
	Ethanol	Warmed: 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.03 mL	125.16 mL	250.31 mL
0.5 mM	5.01 mL	25.03 mL	50.06 mL
1 mM	2.5 mL	12.52 mL	25.03 mL
5 mM	0.5 mL	2.5 mL	5.01 mL

*The above data is based on the productmolecular weight 399.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.