Troglitazone

Catalog No. A11981

Troglitazone是一种选择性PPARγ受体激动剂（鼠和人PPARγ受体的EC50值分别为780和555 nM）。

Product Citations

Julien Allard, .et al. Drug-induced Hepatic Steatosis in Absence of Severe Mitochondrial Dysfunction in HepaRG Cells: Proof of Multiple Mechanism-Based Toxicity, Cell Biol Toxicol, 2020, Jun 14 PMID: 32535746

Technical details

Catalog Num	A11981
M. Wt	441.54
Formula	C24H27NO5S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	97322-87-7
Synonyms	Rezulin
SMILES	CC1=C(C(=C2CCC(OC2=C1C)(C)COC3=CC=C(C=C3)CC4C(=O)NC(=O)S4)C)O

Biological Activity

Troglitazone是一种选择性PPARγ受体激动剂（鼠和人PPARγ受体的EC50值分别为780和555 nM）。

Solubility *

In vitro (25°C)	DMSO	Warmed: 85 mg/mL (192.51 mM)
	Water	Insoluble
	Ethanol	Warmed: 15 mg/mL (33.97 mM)
In vivo	1% CMC Na	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.65 mL	113.24 mL	226.48 mL
0.5 mM	4.53 mL	22.65 mL	45.3 mL
1 mM	2.26 mL	11.32 mL	22.65 mL
5 mM	0.45 mL	2.26 mL	4.53 mL

*The above data is based on the productmolecular weight 441.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.