Gambogic acid

Catalog No. A11988

Gambogic acid是从藤黄汉树中分离出的天然产物。藤黄酸激活半胱氨酸蛋白酶，EC50为0.78-1.64μM，并竞争性抑制Bcl-XL，Bcl-2，Bcl-W，Bcl-B，Bfl-1和Mcl-1，IC50为1.47、1.21、2.02、0.66、1.06和分别为0.79μM。

Technical details

Catalog Num	A11988
M. Wt	628.75
Formula	C38H44O8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2752-65-0
Synonyms
SMILES	CC(=CCC[C@@]1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=C[C@@H]5C[C@@H]6[C@@]4(O3)[C@](C5=O)(OC6(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)C)C

Biological Activity

Targets

Target	Value
Bcl-w	IC50: 0.02μM
Bcl-B	IC50: 0.66μM
Mcl-1	IC50: 0.79μM
Bfl-1	IC50: 1.06μM
Bcl-2	IC50: 1.21μM
Bcl-xL	IC50: 1.47μM
Caspase	EC50	<1.64μM

Solubility *

In vitro (25°C)	DMSO	97 mg/mL (154.27 mM)
	Water	Insoluble
	Ethanol	97 mg/mL (154.27 mM)
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.9 mL	79.52 mL	159.05 mL
0.5 mM	3.18 mL	15.9 mL	31.81 mL
1 mM	1.59 mL	7.95 mL	15.9 mL
5 mM	0.32 mL	1.59 mL	3.18 mL

*The above data is based on the productmolecular weight 628.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.