(S)-10-Hydroxycamptothecin
Catalog No. A11997
(S)-10-Hydroxycamptothecin是喜树碱衍生物,它通过在染色体DNA中产生链断裂并诱导细胞凋亡来抑制DNA拓扑异构酶。
Catalog Num | A11997 |
---|---|
M. Wt | 364.35 |
Formula | C20H16N2O5 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 19685-09-7 |
Synonyms | HCPT;SN38;Ampule;NSC 107124;HYDROCAMPTOTHECINE;HYDROXYCAMPTOTHECIN; |
SMILES | CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O |
(S)-10-Hydroxycamptothecin是喜树碱衍生物,它通过在染色体DNA中产生链断裂并诱导细胞凋亡来抑制DNA拓扑异构酶。
Targets
DNA topoisomerase I | ||||
In vitro (25°C) | DMSO | Warmed: 7 mg/mL (19.21 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 27.45 mL | 137.23 mL | 274.46 mL |
0.5 mM | 5.49 mL | 27.45 mL | 54.89 mL |
1 mM | 2.74 mL | 13.72 mL | 27.45 mL |
5 mM | 0.55 mL | 2.74 mL | 5.49 mL |
*The above data is based on the productmolecular weight 364.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.