SN 38

Catalog No. A12011

SN 38是依立替康(喜树碱的类似物-拓扑异构酶I抑制剂)的活性代谢物。

Product Citations

Chen JC, .et al. In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells, Biomolecules, 2019, Sep 9;9(9) PMID: 31505885
Alibolandi M, .et al. Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38, Artif Cells Nanomed Biotechnol, 2018, May 27:1-12 PMID: 29806500
Bar-Zeev M, .et al. β-Casein micelles for oral delivery of SN-38 and elacridar to overcome BCRP-mediated multidrug resistance in gastric cancer, Eur J Pharm Biopharm, 2018, Dec;133:240-249 PMID: 30367935

Technical details

Catalog Num	A12011
M. Wt	392.4
Formula	C22H20N2O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	86639-52-3
Synonyms	7-Ethyl-10-hydroxycamptothecin, SN38, SN-38
SMILES	CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)[C@@]5(CC)O)O

Biological Activity

SN 38是依立替康(喜树碱的类似物-拓扑异构酶I抑制剂)的活性代谢物。

Targets

Topo I (Cell-free assay)

Solubility *

In vitro	DMSO	20 mg/mL (50.96 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.48 mL	127.42 mL	254.84 mL
0.5 mM	5.1 mL	25.48 mL	50.97 mL
1 mM	2.55 mL	12.74 mL	25.48 mL
5 mM	0.51 mL	2.55 mL	5.1 mL

*The above data is based on the productmolecular weight 392.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.