Tenovin-6

Catalog No. A12305

Tenovin-6是tenovin-1的类似物。Tenovin-6在体外抑制纯化的人SIRT1、SIRT2和SIRT3的蛋白脱乙酰酶活性，IC50值分别为21、10和67 uM。

Product Citations

Igase M,, .et al. Tenovin-6 induces the SIRT-independent cell growth suppression and blocks autophagy flux in canine hemangiosarcoma cell lines, Exp Cell Res, 2019, Dec 28:111810 PMID: 31891684

Technical details

Catalog Num	A12305
M. Wt	454.6
Formula	C25H34N4O2S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1011557-82-6
Synonyms	Tenovin6, Tenovin 6
SMILES	CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C

Biological Activity

Tenovin-6是tenovin-1的类似物。Tenovin-6在体外抑制纯化的人SIRT1、SIRT2和SIRT3的蛋白脱乙酰酶活性，IC50值分别为21、10和67 uM。

Targets

p53	SIRT2	SIRT1	SIRT3
N/A	10 μM	21 μM	67 μM

Solubility *

In vitro	DMSO	87 mg/mL (191.36 mM)
	Water	Warmed: 87 mg/mL (191.36 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22 mL	109.99 mL	219.97 mL
0.5 mM	4.4 mL	22 mL	43.99 mL
1 mM	2.2 mL	11 mL	22 mL
5 mM	0.44 mL	2.2 mL	4.4 mL

*The above data is based on the productmolecular weight 454.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.