Lonafarnib (SCH66336)

Catalog No. A12328

Lonafarnib (SCH66336)是H-ras、K-ras-4B和N-ras的选择性FPTase抑制剂,IC50分别为1.9 nM、5.2 nM和2.8 nM。
  • Stella Liong, .et al. Placental Ras Regulates Inflammation Associated with Maternal Obesity, Mediators Inflamm, 2018, 2018: 3645386 PMID: 30402038
Catalog Num A12328
M. Wt 638.82
Formula C27H31Br2ClN4O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 193275-84-2
Synonyms Sarasar, SCH 66336, SCH66336, SCH-66336
SMILES C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N
Lonafarnib (SCH66336)是H-ras、K-ras-4B和N-ras的选择性FPTase抑制剂,IC50分别为1.9 nM、5.2 nM和2.8 nM。
Targets
H-ras (Cell-free assay) N-ras (Cell-free assay) K-ras-4B (Cell-free assay)
1.9 nM2.8 nM5.2 nM
In vitro DMSO 116 mg/mL (181.58 mM)
Water Insoluble
Ethanol 116 mg/mL (181.58 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.65 mL 78.27 mL 156.54 mL
0.5 mM 3.13 mL 15.65 mL 31.31 mL
1 mM 1.57 mL 7.83 mL 15.65 mL
5 mM 0.31 mL 1.57 mL 3.13 mL

*The above data is based on the productmolecular weight 638.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.