FIIN-2

Catalog No. A12357

FIIN-2是FGFR1-4的不可逆抑制剂，IC50值分别为3.1、4.3、27和45 nM。

Technical details

Catalog Num	A12357
M. Wt	634.73
Formula	C35H38N8O4
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1633044-56-0
Synonyms	FIIN2, FIIN 2
SMILES	O=C1N(C2=CC(OC)=CC(OC)=C2)CC(C=NC(NC3=CC=C(N4CCN(C)CC4)C=C3)=N5)=C5N1CC6=CC=C(NC(C=C)=O)C=C6

Biological Activity

FIIN-2是FGFR1-4的不可逆抑制剂，IC50值分别为3.1、4.3、27和45 nM。

Targets

FGFR1	FGFR2	FGFR3	FGFR4
3.09 nM	4.3 nM	27 nM	45.3 nM

Solubility *

In vitro	DMSO	62 mg/mL (97.67 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.75 mL	78.77 mL	157.55 mL
0.5 mM	3.15 mL	15.75 mL	31.51 mL
1 mM	1.58 mL	7.88 mL	15.75 mL
5 mM	0.32 mL	1.58 mL	3.15 mL

*The above data is based on the productmolecular weight 634.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.