Cilengitide trifluoroacetate

Catalog No. A12371

Cilengitide trifluoroacetate是一种具有潜在抗肿瘤活性的环状精氨酸-甘氨酸-天冬氨酸肽。西仑吉肽结合并抑制α(v)β(3)和α(v)β(5)整联蛋白的活性，从而抑制内皮细胞-细胞相互作用、内皮细胞-基质相互作用和血管生成。

Product Citations

Yi Han Tan, .et al. Complement-activated vitronectin enhances the invasion of nonphagocytic cells by bacterial pathogens Burkholderia and Klebsiella, Cell Microbiol, 2017, Aug;19(8) PMID: 28186697

Technical details

Catalog Num	A12371
M. Wt	702.7
Formula	C29H41N8O9F3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	199807-35-7
Synonyms	EMD 12197,EMD-85189,EMD-121974,NSC-707544,D03497
SMILES	CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)Cc2ccccc2)CC(=O)O)CCCNC(=N)N.C(=O)(C(F)(F)F)O

Biological Activity

Targets

αvβ3 receptor (Cell-free assay)	αvβ5 receptor (Cell-free assay)
4.1 nM	79 nM

Solubility *

In vitro	DMSO	89 mg/mL (126.66 mM)
	Water	7 mg/mL (9.96 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.23 mL	71.15 mL	142.31 mL
0.5 mM	2.85 mL	14.23 mL	28.46 mL
1 mM	1.42 mL	7.12 mL	14.23 mL
5 mM	0.28 mL	1.42 mL	2.85 mL

*The above data is based on the productmolecular weight 702.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.