Reparixin

Catalog No. A12383

Reparixin是两种CXCL8受体CXCR1/2的有效抑制剂，它抑制CXCR2介导的细胞迁移（IC50 = 100 nM），而它强烈地阻断CXCR1介导的趋化性（IC50 = 1 nM）。

Product Citations

Naour AL, .et al. Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors, J Mol Cell Biol, 2019, Sep 3 PMID: 31504643
Wigenstam E, .et al. N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury, Toxicology, 2015, Feb 3;328:40-7 PMID: 25497111

Technical details

Catalog Num	A12383
M. Wt	283.39
Formula	C14H21NO3S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	266359-83-5
Synonyms	DF 1681Y; Repertaxin
SMILES	C[C@H](C1=CC=C(C=C1)CC(C)C)C(=O)NS(=O)(=O)C

Biological Activity

Reparixin是两种CXCL8受体CXCR1/2的有效抑制剂，它抑制CXCR2介导的细胞迁移（IC50 = 100 nM），而它强烈地阻断CXCR1介导的趋化性（IC50 = 1 nM）。

Solubility *

In vitro	DMSO	52 mg/mL (183.49 mM)
	Water	Insoluble
	Ethanol	52 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.29 mL	176.44 mL	352.87 mL
0.5 mM	7.06 mL	35.29 mL	70.57 mL
1 mM	3.53 mL	17.64 mL	35.29 mL
5 mM	0.71 mL	3.53 mL	7.06 mL

*The above data is based on the productmolecular weight 283.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.