XL019
Catalog No. A12394
XL019是janus相关激酶2 (JAK-2)的生物可利用抑制剂,具有潜在的抗肿瘤活性。
Catalog Num | A12394 |
---|---|
M. Wt | 444.53 |
Formula | C25H28N6O2 |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 945755-56-6 |
Synonyms | XL 019, XL-019 |
SMILES | C1C[C@H](NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5 |
XL019是janus相关激酶2 (JAK-2)的生物可利用抑制剂,具有潜在的抗肿瘤活性。
Targets
Target | Value |
---|---|
JAK2 | IC50: 2.2nM |
PDGFRβ | IC50: 125.4nM |
JAK1 | IC50: 134.3nM |
FLT3 | IC50: 139.7nM |
JAK3 | IC50: 214.2nM |
c-Kit | IC50: 225.8nM |
p70S6K | IC50: 313.8nM |
TYK2 | IC50: 348.3nM |
MLK1 | IC50: 370.0nM |
IKKβ | IC50: 375.4nM |
KDR | IC50: 483.6nM |
PDGFRα | IC50: 546.7nM |
FLT4 | IC50: 554.5nM |
FLT1 | IC50: 910.5nM |
In vitro | DMSO | 14 mg/mL (31.49 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 22.5 mL | 112.48 mL | 224.96 mL |
0.5 mM | 4.5 mL | 22.5 mL | 44.99 mL |
1 mM | 2.25 mL | 11.25 mL | 22.5 mL |
5 mM | 0.45 mL | 2.25 mL | 4.5 mL |
*The above data is based on the productmolecular weight 444.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.