XL388

Catalog No. A12395

XL388是哺乳动物雷帕霉素靶标(mTOR)的一类新型高效、选择性、ATP竞争性生物可利用抑制剂。

Technical details

Catalog Num	A12395
M. Wt	455.5
Formula	C23H22FN3O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1251156-08-7
Synonyms	XL 388, XL-388
SMILES	CC1=C(C=CC(=C1F)S(=O)(=O)C)C(=O)N2CCOC3=C(C2)C=C(C=C3)C4=CN=C(C=C4)N

Biological Activity

XL388是哺乳动物雷帕霉素靶标(mTOR)的一类新型高效、选择性、ATP竞争性生物可利用抑制剂。

Targets

Target	Value
mTORC1	IC50: 8nM
mTOR	IC50: 9.9nM
mTORC2	IC50: 166nM
PI3Kα	IC50: >3μM
CYP2C9	IC50: 10.6μM
CYP2C8	IC50: >20μM
CYP2D6	IC50: >20μM
CYP3A4	IC50: 24.6μM

Solubility *

In vitro (25°C)	DMSO	21 mg/mL (46.1 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.95 mL	109.77 mL	219.54 mL
0.5 mM	4.39 mL	21.95 mL	43.91 mL
1 mM	2.2 mL	10.98 mL	21.95 mL
5 mM	0.44 mL	2.2 mL	4.39 mL

*The above data is based on the productmolecular weight 455.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.