IPI-145 (Duvelisib, INK1197)

Catalog No. A12422

IPI-145 (Duvelisib,INK1197)是磷酸肌醇-3激酶(PI3K)δ和γ亚型的生物可利用、高选择性和有效的小分子抑制剂，具有潜在的免疫调节和抗肿瘤活性。

Technical details

Catalog Num	A12422
M. Wt	416.86
Formula	C22H17ClN6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1201438-56-3
Synonyms	IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197
SMILES	C[C@@H](C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5

Biological Activity

IPI-145 (Duvelisib,INK1197)是磷酸肌醇-3激酶(PI3K)δ和γ亚型的生物可利用、高选择性和有效的小分子抑制剂，具有潜在的免疫调节和抗肿瘤活性。

Targets

Target	Value
PI3Kδ	ki: 23pM
PI3Kγ	ki: 243pM
PI3Kδ	ki: 23pM
PI3Kβ	ki: 1564pM
PI3Kα	ki: 25900pM
PI3Kγ	ki: 243pM

Solubility *

In vitro (25°C)	DMSO	76 mg/mL (182.31 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.99 mL	119.94 mL	239.89 mL
0.5 mM	4.8 mL	23.99 mL	47.98 mL
1 mM	2.4 mL	11.99 mL	23.99 mL
5 mM	0.48 mL	2.4 mL	4.8 mL

*The above data is based on the productmolecular weight 416.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.