SU 5416 (Semaxinib)

Catalog No. A12437

SU 5416 (Semaxinib)是血管内皮生长因子受体（VEGFR）的抑制剂，它还抑制其他酪氨酸激酶KIT，MET，FLT3和RET。

Product Citations

Guangyan Zhang, .et al. Sulforaphane Does Not Protect Right Ventricular Systolic and Diastolic Functions in Nrf2 Knockout Pulmonary Artery Hypertension Mice, Cardiovasc Drugs Ther, 2022, Feb 14 PMID: 35157168
Michel R. Corboz, .et al. Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension, Eur J Pharmacol, 2022, 916: 174484 PMID: 34508752
Avner Adini, .et al. PR1P Stabilizes VEGF and Upregulates its Signaling to Reduce Elastase Induced Murine Emphysema, Am J Respir Cell Mol Biol, 2020, Jul 14 PMID: 32663413
Yin Kang, .et al. Sulforaphane Prevents Right Ventricular Injury and Reduces Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension, Am J Physiol Heart Circ Physiol, 2020, Apr 1;318(4):H853-H866 PMID: 32108526

Technical details

Catalog Num	A12437
M. Wt	238.28
Formula	C15H14N2O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	204005-46-9
Synonyms	SU-5416, SU5416
SMILES	CC1=CC(=C(N1)/C=C\2/C3=CC=CC=C3NC2=O)C

Biological Activity

SU 5416 (Semaxinib)是血管内皮生长因子受体（VEGFR）的抑制剂，它还抑制其他酪氨酸激酶KIT，MET，FLT3和RET。

Solubility *

In vitro (25°C)	DMSO	19 mg/mL (79.73 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (8.39 mM)
In vivo	5% DMSO+40%PEG 300+ 5% Tween80 + ddH2O	0.4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	41.97 mL	209.84 mL	419.67 mL
0.5 mM	8.39 mL	41.97 mL	83.93 mL
1 mM	4.2 mL	20.98 mL	41.97 mL
5 mM	0.84 mL	4.2 mL	8.39 mL

*The above data is based on the productmolecular weight 238.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.