BMS 299897
Catalog No. A12444
BMS 299897是一种有效的γ-分泌酶抑制剂（IC50 = 12 nM）。在体外抑制Aβ40和Aβ42的形成（IC50值分别为7.4和7.9 nM），并在体内降低脑，血浆和脑脊髓液中的Aβ。
- Chao Liu, .et al. APP upregulation contributes to retinal ganglion cell degeneration via JNK3, Cell Death Differ, 2018, Apr; 25(4): 661-676 PMID: 29238071
| Catalog Num | A12444 |
|---|---|
| M. Wt | 511.94 |
| Formula | C24H21ClF3NO4S |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 290315-45-6 |
| Synonyms | BMS 299897 |
| SMILES | C[C@H](C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl |
BMS 299897是一种有效的γ-分泌酶抑制剂（IC50 = 12 nM）。在体外抑制Aβ40和Aβ42的形成（IC50值分别为7.4和7.9 nM），并在体内降低脑，血浆和脑脊髓液中的Aβ。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.53 mL | 97.67 mL | 195.34 mL |
| 0.5 mM | 3.91 mL | 19.53 mL | 39.07 mL |
| 1 mM | 1.95 mL | 9.77 mL | 19.53 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.91 mL |
*The above data is based on the productmolecular weight 511.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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