AT13148

Catalog No. A12464

AT13148是一种新型多AGC激酶抑制剂，具有强大的药效和抗肿瘤活性，与其他AKT抑制剂相比，具有独特的作用机理。

Technical details

Catalog Num	A12464
M. Wt	313.78
Formula	C17H16ClN3O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1056901-62-2
Synonyms	AT 13148, AT-13148
SMILES	C1=CC(=CC=C1C2=CNN=C2)[C@@](CN)(C3=CC=C(C=C3)Cl)O

Biological Activity

AT13148是一种新型多AGC激酶抑制剂，具有强大的药效和抗肿瘤活性，与其他AKT抑制剂相比，具有独特的作用机理。

Targets

Target	Value
PKA	IC50: 3nM
ROCK2	IC50: 4nM
ROCK1	IC50: 6nM
p70S6K	IC50: 8nM
Akt1	IC50: 38nM
Akt3	IC50: 50nM
SGK3	IC50: 63nM
RSK1	IC50: 85nM
Akt2	IC50: 402nM
Chk2	IC50: 860nM
AuroraB	IC50: 1860nM

Solubility *

In vitro	DMSO	55 mg/mL (175.28 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.87 mL	159.35 mL	318.69 mL
0.5 mM	6.37 mL	31.87 mL	63.74 mL
1 mM	3.19 mL	15.93 mL	31.87 mL
5 mM	0.64 mL	3.19 mL	6.37 mL

*The above data is based on the productmolecular weight 313.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.