TCS ERK 11e (VX-11e)

Catalog No. A12505

TCS ERK 11e (VX-11e)是一种有效且选择性的细胞外信号相关激酶2(ERK2)抑制剂(ERK2,GSK-3,Aurora激酶A和Cdk2的Ki值分别<2、395、540和852 nM)。有效阻断HT29细胞的增殖(IC50 = 48 nM)。
Catalog Num A12505
M. Wt 500.35
Formula C24H20Cl2FN5O2
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 896720-20-0
Synonyms
SMILES CC1=CN=C(N=C1C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl
TCS ERK 11e (VX-11e)是一种有效且选择性的细胞外信号相关激酶2(ERK2)抑制剂(ERK2,GSK-3,Aurora激酶A和Cdk2的Ki值分别<2、395、540和852 nM)。有效阻断HT29细胞的增殖(IC50 = 48 nM)。
Targets
Target Value
ERK2ki: <2nM
GSK3ki: 400nM
AURAki: 540nM
CDK2ki: 850nM
FLT3ki: 1.4μM
ROCK1ki: 1.4μM
JNK3ki: 1.4μM
TAK1ki: 3μM
PKAki: >4μM
SRCki: >4μM
JAK2ki: >4μM
JAK3ki: >4μM
SYKki: >4μM
METki: >4μM
IRAK4ki: >4μM
AKT3ki: >4μM
KDRki: >4μM
MEK1ki: >4μM
P38αki: >4μM
COTki: >4μM
ITKki: >4μM
MEKK3ki: >4μM
PLK1ki: >4μM
ZAP70ki: >4μM
IKki: ki: >5μM
NIKki: >5μM
CITki: >10μM
FAKki: >10μM
In vitro DMSO 94 mg/mL (187.87 mM)
Water Insoluble
Ethanol 15 mg/mL (29.97 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.99 mL 99.93 mL 199.86 mL
0.5 mM 4 mL 19.99 mL 39.97 mL
1 mM 2 mL 9.99 mL 19.99 mL
5 mM 0.4 mL 2 mL 4 mL

*The above data is based on the productmolecular weight 500.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.