CHS-828 (GMX1778)

Catalog No. A12515

CHS-828 (GMX1778)是NAD+生物合成酶NAMPT的有效抑制剂，IC50 <25 nM。

Technical details

Catalog Num	A12515
M. Wt	371.86
Formula	C19H22ClN5O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	200484-11-3
Synonyms	GMX1778, GMX-1778, GMX 1778, CHS828, CHS 828
SMILES	ClC1=CC=C(OCCCCCC/N=C(\N=C2C=CNC=C/2)NC#N)C=C1

Biological Activity

CHS-828 (GMX1778)是NAD+生物合成酶NAMPT的有效抑制剂，IC50 <25 nM。

Targets

NAMPT	NAMPT
25 nM	120 nM(Kd)

Solubility *

In vitro	DMSO	64 mg/mL (172.1 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.89 mL	134.46 mL	268.92 mL
0.5 mM	5.38 mL	26.89 mL	53.78 mL
1 mM	2.69 mL	13.45 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL

*The above data is based on the productmolecular weight 371.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.