Losmapimod (GW856553X)

Catalog No. A12526

Losmapimod，也称为GW856553或GW856553X，是葛兰素史克（GlaxoSmithKline）开发的药物，可作为酶家族的选择性抑制剂，称为p38促分裂原活化蛋白激酶，其作用于p38α和p38β的pKi分别为8.1和7.6 。

Technical details

Catalog Num	A12526
M. Wt	383.46
Formula	C22H26FN3O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	585543-15-3
Synonyms	GW856553, GW-856553, GW 856553, GW856553X
SMILES	CC1=C(C=C(C=C1C2=NC=C(C=C2)C(=O)NCC(C)(C)C)C(=O)NC3CC3)F

Biological Activity

Targets

p38α	p38β
8.1(pKi)	7.6(pKi)

Solubility *

In vitro	DMSO	72 mg/mL (187.76 mM)
	Water	Insoluble
	Ethanol	Warmed: 39 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.08 mL	130.39 mL	260.78 mL
0.5 mM	5.22 mL	26.08 mL	52.16 mL
1 mM	2.61 mL	13.04 mL	26.08 mL
5 mM	0.52 mL	2.61 mL	5.22 mL

*The above data is based on the productmolecular weight 383.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.