RN486

Catalog No. A12535

RN486是一种布鲁顿酪氨酸激酶（Btk）抑制剂。

Technical details

Catalog Num	A12535
M. Wt	606.7
Formula	C35H35FN6O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1242156-23-5
Synonyms	RN-486,RN 486
SMILES	CN1CCN(CC1)C2=CN=C(C=C2)NC3=CC(=CN(C3=O)C)C4=C(C(=CC=C4)N5C=CC6=CC(=CC(=C6C5=O)F)C7CC7)CO

Biological Activity

RN486是一种布鲁顿酪氨酸激酶（Btk）抑制剂。

Targets

BTK
4 nM

Solubility *

In vitro (25°C)	DMSO	Warmed: 61 mg/mL (100.54 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+10% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.48 mL	82.41 mL	164.83 mL
0.5 mM	3.3 mL	16.48 mL	32.97 mL
1 mM	1.65 mL	8.24 mL	16.48 mL
5 mM	0.33 mL	1.65 mL	3.3 mL

*The above data is based on the productmolecular weight 606.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.