FRAX597

Catalog No. A12553

FRAX597是一种小分子吡啶并嘧啶酮，是I类PAK（PAK1 IC50 = 8 nM，PAK2 IC50 = 13 nM，PAK3 IC50 = 19 nM）的有效和ATP竞争性抑制剂。

Product Citations

Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.

Technical details

Catalog Num	A12553
M. Wt	558.1
Formula	C29H28ClN7OS
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1286739-19-2
Synonyms	FRAX 597, FRAX-597
SMILES	CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C

Biological Activity

FRAX597是一种小分子吡啶并嘧啶酮，是I类PAK（PAK1 IC50 = 8 nM，PAK2 IC50 = 13 nM，PAK3 IC50 = 19 nM）的有效和ATP竞争性抑制剂。

Targets

PAK1	PAK2	PAK2	PAK3
8 nM	13 nM	13 nM	19 nM

Solubility *

In vitro	DMSO	Warmed: 13 mg/mL (23.29 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (1.79 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.92 mL	89.59 mL	179.18 mL
0.5 mM	3.58 mL	17.92 mL	35.84 mL
1 mM	1.79 mL	8.96 mL	17.92 mL
5 mM	0.36 mL	1.79 mL	3.58 mL

*The above data is based on the productmolecular weight 558.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.