BMS-345541

Catalog No. A12559

BMS-345541是IKK-2和IKK-1催化亚基的高度选择性抑制剂，IC50为0.3 μM和4 μM。

Technical details

Catalog Num	A12559
M. Wt	255.32
Formula	C14H17N5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	445430-58-0
Synonyms	BMS345541, BMS 345541
SMILES	CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN

Biological Activity

BMS-345541是IKK-2和IKK-1催化亚基的高度选择性抑制剂，IC50为0.3 μM和4 μM。

Targets

IKK2 (Cell-free assay)	IKK1 (Cell-free assay)
0.3 μM	4 μM

Solubility *

In vitro	DMSO	8 mg/mL (31.32 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	39.17 mL	195.83 mL	391.67 mL
0.5 mM	7.83 mL	39.17 mL	78.33 mL
1 mM	3.92 mL	19.58 mL	39.17 mL
5 mM	0.78 mL	3.92 mL	7.83 mL

*The above data is based on the productmolecular weight 255.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.