(+)-Bicuculline

Catalog No. A12590

(+)-Bicuculline是一种经典的GABAA拮抗剂。

Product Citations

Maryam Adenike Salaudeen, .et al. Anticonvulsant Activity of Tapinanthus dodoneifolius (DC.) Danser in Chicks and Mice: A Potential Source of Novel Anticonvulsant Agent, J Pharmacy and Drug Innovations, 2022, 3(4)

Technical details

Catalog Num	A12590
M. Wt	367.36
Formula	C20H17NO6
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	485-49-4
Synonyms
SMILES	CN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3

Biological Activity

(+)-Bicuculline是一种经典的GABAA拮抗剂。

Targets

GABAA receptor
2 μM

Solubility *

In vitro	DMSO	Warmed: 18 mg/mL (48.99 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.22 mL	136.11 mL	272.21 mL
0.5 mM	5.44 mL	27.22 mL	54.44 mL
1 mM	2.72 mL	13.61 mL	27.22 mL
5 mM	0.54 mL	2.72 mL	5.44 mL

*The above data is based on the productmolecular weight 367.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.