lorcaserin hydrochloride (APD-356)

Catalog No. A12598

lorcaserin hydrochloride (APD-356)是血清素2C受体激动剂，可指示与减少热量饮食和增加体育锻炼以减轻慢性体重成人管理。

Product Citations

Li Li, .et al. Delineating a serotonin 1B receptor circuit for appetite suppression in mice, J Exp Med, 2022, Aug 1;219(8):e20212307 PMID: 35796804
Henrik H. Hansen, .et al. Whole-brain activation signatures of weight-lowering drugs, Mol Metab, 2021, May;47:101171 PMID: 33529728

Technical details

Catalog Num	A12598
M. Wt	232.15
Formula	C11H14ClN.HCl
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	846589-98-8
Synonyms	APD-356,APD356,APD 356, BELVIQ
SMILES	C[C@H]1CNCCC2=C1C=C(C=C2)Cl.Cl

Biological Activity

lorcaserin hydrochloride (APD-356)是血清素2C受体激动剂，可指示与减少热量饮食和增加体育锻炼以减轻慢性体重成人管理。

Targets

Human 5-HT2C	Rat 5-HT2C
15 nM(Ki)	29 nM(Ki)

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	43.08 mL	215.38 mL	430.76 mL
0.5 mM	8.62 mL	43.08 mL	86.15 mL
1 mM	4.31 mL	21.54 mL	43.08 mL
5 mM	0.86 mL	4.31 mL	8.62 mL

*The above data is based on the productmolecular weight 232.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.