Combretastatin A4

Catalog No. A12601

Combretastatin A4是在体内和体外的抗肿瘤，抗血管生成和抗转移药。Combretastatin A4是一种微管靶向剂，可与β-微管蛋白结合，Kd为0.4μM。

Technical details

Catalog Num	A12601
M. Wt	316.35
Formula	C18H20O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	117048-59-6
Synonyms	CRC 87-09, NSC 817373
SMILES	COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)O

Biological Activity

Combretastatin A4是在体内和体外的抗肿瘤，抗血管生成和抗转移药。Combretastatin A4是一种微管靶向剂，可与β-微管蛋白结合，Kd为0.4μM。

Solubility *

In vitro (25°C)	DMSO	58 mg/mL (183.34 mM)
	Water	Insoluble
	Ethanol	Warmed: 31 mg/mL (97.99 mM)
In vivo	5% DMSO+50% PEG 300+ddH2O	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.61 mL	158.05 mL	316.11 mL
0.5 mM	6.32 mL	31.61 mL	63.22 mL
1 mM	3.16 mL	15.81 mL	31.61 mL
5 mM	0.63 mL	3.16 mL	6.32 mL

*The above data is based on the productmolecular weight 316.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Combretastatin A4

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions