ABC294640

Catalog No. A12614

ABC294640是一种口服的芳基金刚烷化合物，是鞘氨醇激酶2（SK2）的选择性抑制剂，Ki 为 9.8 μM，具有潜在的抗肿瘤活性。

Technical details

Catalog Num	A12614
M. Wt	380.16554
Formula	C23H25ClN2O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	915385-81-8
Synonyms	ABC-294640, ABC 294640
SMILES	C1[C@H]2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl

Biological Activity

ABC294640是一种口服的芳基金刚烷化合物，是鞘氨醇激酶2（SK2）的选择性抑制剂，Ki 为 9.8 μM，具有潜在的抗肿瘤活性。

Targets

SphK2
60 μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 75 mg/mL (196.89 mM)
	Water	Insoluble
	Ethanol	28 mg/mL (73.5 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.3 mL	131.52 mL	263.04 mL
0.5 mM	5.26 mL	26.3 mL	52.61 mL
1 mM	2.63 mL	13.15 mL	26.3 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

*The above data is based on the productmolecular weight 380.16554. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.