Sildenafil

Catalog No. A12631

Sildenafil是选择性磷酸二酯酶5（PDE5）抑制剂之一（IC50 = 5.22 nM），被认为是治疗勃起功能障碍的最佳方法。

Product Citations

Michel R. Corboz, .et al. Treprostinil palmitil inhibits the hemodynamic and histopathological changes in the pulmonary vasculature and heart in an animal model of pulmonary arterial hypertension, Eur J Pharmacol, 2022, 916: 174484 PMID: 34508752

Technical details

Catalog Num	A12631
M. Wt	474.58
Formula	C22H30N6O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	139755-83-2
Synonyms	Revatio, UK-92480, Viagra
SMILES	CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C

Biological Activity

Sildenafil是选择性磷酸二酯酶5（PDE5）抑制剂之一（IC50 = 5.22 nM），被认为是治疗勃起功能障碍的最佳方法。

Targets

Phosphodiesterase 5

Solubility *

In vitro	DMSO	Insoluble
	Water	12 mg/mL (25.28 mM)
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.07 mL	105.36 mL	210.71 mL
0.5 mM	4.21 mL	21.07 mL	42.14 mL
1 mM	2.11 mL	10.54 mL	21.07 mL
5 mM	0.42 mL	2.11 mL	4.21 mL

*The above data is based on the productmolecular weight 474.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.