ONX-0914

Catalog No. A12653

ONX 0914是有效，选择性的免疫蛋白酶体亚基LMP7的抑制剂，在自身免疫性疾病（如类风湿性关节炎，炎性肠病和狼疮）中具有潜在的治疗应用。ONX 0914被设计为一种有效的免疫蛋白酶抑制剂，对组成型蛋白酶体的交叉反应最小。

Product Citations

Yuki Sasaki, .et al. Blockade of the CXCR3/CXCL10 axis ameliorates inflammation caused by immunoproteasome dysfunction, JCI Insight, 2022, Apr 8;7(7) PMID: 35393946
Ming-Shu Mo, .et al. Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo, Transl Neurodegener, 2018, 7: 19 PMID: 30128145
Ohkusu-Tsukada K, .et al. The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice, Int Arch Allergy Immunol, 2018, 176(2):91-100 PMID: 29669333
Arimochi H, .et al. Differentiation of preadipocytes and mature adipocytes requires PSMB8, Sci Rep, 2016, May 26;6:26791 PMID: 27225296

Technical details

Catalog Num	A12653
M. Wt	580.67
Formula	C31H40N4O7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	960374-59-8
Synonyms	ONX0914, ONX 0914, PR-957
SMILES	C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)OC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)[C@]3(CO3)C)NC(=O)CN4CCOCC4

Biological Activity

Targets

LMP7 (Cell-free assay)
~10 nM

Solubility *

In vitro (25°C)	DMSO	87 mg/mL (149.82 mM)
	Water	Insoluble
	Ethanol	87 mg/mL (149.82 mM)
In vivo	2% DMSO+castor oil	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.22 mL	86.11 mL	172.21 mL
0.5 mM	3.44 mL	17.22 mL	34.44 mL
1 mM	1.72 mL	8.61 mL	17.22 mL
5 mM	0.34 mL	1.72 mL	3.44 mL

*The above data is based on the productmolecular weight 580.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.