Verteporfin

Catalog No. A12658

Verteporfin是抑制TEAD-YAP缔合和YAP诱导的肝过度生长的小分子。它也是一种有效的第二代光敏剂，衍生自卟啉。

Product Citations

Po-Ju Lee, .et al. Epstein-Barr viral product-containing exosomes promote fibrosis and nasopharyngeal carcinoma progression through activation of YAP1/FAPα signaling in fibroblasts, J Exp Clin Cancer Res, 2022, Aug 20;41(1):254 PMID: 35986369
Wang Y, .et al. Verteporfin inhibits lipopolysaccharide-induced inflammation by multiple functions in RAW 264.7 cells, Toxicol Appl Pharmacol, 2019, 2019 Dec 5;387:114852 PMID: 31812773
Abe T, .et al. Role of YAP Activation in Nuclear Receptor CAR-Mediated Proliferation of Mouse Hepatocytes, Toxicol Sci, 2018, Oct 1;165(2):408-419 PMID: 29893953

Technical details

Catalog Num	A12658
M. Wt	718.79
Formula	C41H42N4O8
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	129497-78-5
Synonyms	Visudyne, DB00460??CL 318,952??Benzoporphyrin D??Bpd-MA??AIDS350621??AIDS-350621??Benzoporphyrin derivative monoacid ring A.
SMILES	O=C(O)CCC1=C(C)C(/C=C2C(C=C)=C(C)/C(N/2)=C/3)=N/C1=C\C(N4)=C(CCC(OC)=O)C(C)=C4/C=C5[C@]6(C)[C@H](C(OC)=O)C(C(OC)=O)=CC=C6C3=N/5

Biological Activity

Verteporfin是抑制TEAD-YAP缔合和YAP诱导的肝过度生长的小分子。它也是一种有效的第二代光敏剂，衍生自卟啉。

Targets

VDA (Endothelial cells)

Solubility *

In vitro	DMSO	89 mg/mL (123.82 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.91 mL	69.56 mL	139.12 mL
0.5 mM	2.78 mL	13.91 mL	27.82 mL
1 mM	1.39 mL	6.96 mL	13.91 mL
5 mM	0.28 mL	1.39 mL	2.78 mL

*The above data is based on the productmolecular weight 718.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.