PJ 34 hydrochloride
Catalog No. A12665
PJ 34 hydrochloride是聚(ADP-核糖)聚合酶(PARP)(EC50 = 20 nM)的有效抑制剂。
- Alvin Z.Lu, .et al. Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation, Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269
- Wigle TJ, .et al. Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes, SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104
Catalog Num | A12665 |
---|---|
M. Wt | 331.8 |
Formula | C17H17N3O2.HCl |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 344458-15-7 |
Synonyms | PJ34, PJ-34 |
SMILES | CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl |
PJ 34 hydrochloride是聚(ADP-核糖)聚合酶(PARP)(EC50 = 20 nM)的有效抑制剂。
In vitro (25°C) | DMSO | 57 mg/mL (171.79 mM) | |
Water | 57 mg/mL (171.79 mM) | ||
Ethanol | Insoluble | ||
In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 14 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 30.14 mL | 150.69 mL | 301.39 mL |
0.5 mM | 6.03 mL | 30.14 mL | 60.28 mL |
1 mM | 3.01 mL | 15.07 mL | 30.14 mL |
5 mM | 0.6 mL | 3.01 mL | 6.03 mL |
*The above data is based on the productmolecular weight 331.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.